KryoAir, the revolutionary air-based refrigeration system for freeze dryers

July 2, 2024
KryoAir, the revolutionary air-based refrigeration system for freeze dryers

IMA Life collaborated with MIRAI Intex and the US company ACT in developing this “pioneering sustainable refrigeration system” recently awarded at Interphex NY and presented at Achema 2024

Press release issued by IMA Life on 20th of June 2024

KryoAir is a revolutionary air-based refrigeration system for freeze dryers designed and manufactured by IMA Life. In an industry where traditional refrigeration methods often fall short due to environmental concerns and safety regulations, KryoAir stands out as a beacon of innovation and progress. Breaking away from reliance on high-GWP gases and flammable mediums, KryoAir introduces a paradigm shift in refrigeration technology.

Awarded as a “pioneering sustainable refrigeration system” (IMA Life won the Best New Product/Service) at the recent Interphex New York trade show, KryoAir was launched just last year and epitomises IMA Life’s pioneering approach to pharmaceutical manufacturing technologies, especially concerning the freeze-drying and aseptic processing areas. In fact, this system not only avoids the use of high-GWP gases, but ensures consistent cooling output across varying temperatures for freeze-drying applications with an almost maintenance-free concept. IMA Life collaborated with the US-based company ACT, along with MIRAI Intex of the Czech Republic in developing this revolutionary system.

At its core lies the air cycle technology powered by a turbo-compressor-expander, developed and supplied by MIRAI Intex, augmented by the revolutionary Cold Thermal Energy Storage (CTES) system from ACT, a true game-changer in the field. Unlike anything seen before, CTES harnesses the power of phase-transitioning compounds to maximise capacity per unit of volume. This breakthrough innovation not only enhances efficiency but also enables the turbo-compressor-expander technology to support intensive and discontinuous energy applications, like freeze dryers.

Pairing CTES with the MIRAI Cold refrigeration machine, KryoAir transforms a well-established technology into a powerhouse of clean energy utilisation. This dynamic synergy allows KryoAir to achieve extreme low temperatures with unprecedented efficiency, all while maintaining a compact and reliable design.

The benefits of KryoAir extend beyond environmental sustainability and safety. Its single-stage, oil-free turbo compressor-expander ensures reliability and durability, requiring minimal maintenance. Moreover, its ability to deliver consistent cooling output across varying temperatures sets a new standard in refrigeration technology.

Making the lyophilisation process a more sustainable one, KryoAir can be fitted to IMA’s LYOMAX and LYOFAST freeze dryers.

Learn more about KryoAir and IMA Life freeze-drying solutions here:

About IMA Life

IMA Life is part of IMA Group, world leader in the design and manufacture of automatic machines for the processing and packaging of pharmaceuticals, cosmetics, food, tea and coffee, as well as in the automation of industrial processes. IMA Life, which includes the production sites of IMA Life Calenzano, IMA Life Pharmasiena, IMA Life North America, IMA Life Beijing and IMA Life Shanghai, offers a comprehensive product portfolio to process liquids and powders in aseptic and non-aseptic environments: vial and ampoule washers, depyrogenating tunnels, decontamination technology, filling and closing machines for Ready-To-Use vials, ampoules and pre-capped cartridges for medium and high-speed processing, gloveless solutions for ATMPs/cell & gene therapies, powder microdosing and macrodosing machines, cappers, containment solutions, including Restricted Area Barrier Systems and isolators, lyophilisation process developments and continuous aseptic spray freeze drying technology, industrial, pilot, laboratory freeze dryers and automatic and semi-automatic vial loading and unloading systems for freeze dryers. Last but not least, assembly and labelling machines for syringes, labelling machines for vials, ampoules, shaped containers, pre-filled pens, Blow-Fill-Seal single-dose containers and cartons with the latest serialization systems. Blowing machines, depackers, tray loaders and other ancillary equipment are also available.

For more information, visit: and

About Advanced Cooling Technologies, Inc. (ACT)

Advanced Cooling Technologies, Inc. (ACT) is a global leader in the design and manufacturing of thermal management solutions across a wide range of industries. With expertise in passive and active thermal control, above and sub-ambient cooling and temperature ranges spanning from cryogenic to liquid metal, ACT develops, builds, and tests some of the most complex and high performing thermal management systems fielded in the world. With expertise in harsh environment applications routinely experience in space and defense, to high quality standard of the medical market, to a wide range of indoor and outdoor energy efficient industrial solutions; ACT’s products can be seen solving the most challenging applications in many industries. ACT is based out of the United States with an office in the EU and representatives globally.

For more information, visit:

About MIRAI INTEX s.r.o

MIRAI Intex is revolutionizing refrigeration technology by making it more efficient and eco-friendlier through innovative developments and the use of air. Its advanced solutions under the brands MIRAI Cold and MIRAI X CRYO are crucial for fostering sustainable growth across various industries worldwide. With a strong portfolio of patents and innovations bolstering its cutting-edge technologies, MIRAI Intex is expanding its footprint into new markets, providing state-of-the-art solutions for the pharmaceutical, energy, technological, chemical, and food sectors. As pioneers in ecologically neutral ultra-low temperature refrigeration, MIRAI Intex is dedicated to reducing greenhouse gas emissions and delivering high efficiency, reliability, and zero Global Warming Potential (GWP).

For more information, visit: